Early brain development, especially how transient and other early circuits shape the functional organization of the brain and how these circuits control the critical period.
The mammalian brain contains billions of neurons that in primary sensory areas provide an exquisite representation of the external world. These primary sensory areas contain topographic maps of sensory stimulus features (i.e. ocular dominance and orientation in visual cortex or tonotopy in auditory cortex). This functional architecture is not hard-wired, but its development depends on neuronal activity and sensory experience. Our research focuses on answering the critical questions of how this architecture emerges and how experience shapes this process.
To answer these questions, we investigate the circuits of the developing and adult brain from a single cell level to large assemblies of neurons by using advanced imaging and electrophysiological methods such as in vivo and in vitro 2-photon Ca2+-imaging and patch clamp recordings. We combine these techniques with optogenetic methods to selectively activate and silence specific microcircuits. We integrate this information in large-scale computational models of the developing brain in order to understand what role every circuit plays in development.
Our work to date has identified subplate neurons as a crucial component of the developing thalamocortical system. Without these neurons cortical development does not proceed normally. We thus investigate how these neurons promote normal development and plasticity of the cerebral cortex and if there are other circuits present at other ages that play similar functions.
Dipl.Ing. (MSE), Electrical Engineering, Technische Universität Berlin, Germany, 1994
Ph.D., Biomedical Engineering, The Johns Hopkins University, 2000 Mentors: Eric Young, Paul Manis
Post-Doctoral, Neurobiology, Harvard Medical School, 2000-2005 Mentor: Carla Shatz
Instructor, Neurobiology, Harvard Medical School, 2005-2007
Assistant Professor, Biology, UMd, College Park, 2007-2012
Associate Professor, Biology, UMd, College Park, 2012-
Honors and Awards
Ralph E. Powe Junior Faculty Enhancement Award (Oak Ridge Associated Universities), 2007
NARSAD Junior Investigator Award (Brain and Behavior Research Foundation), 2009
Alfred P. Sloan Foundation Research Fellowship, 2010
Burt Evans Award, NOHR 2013
For a current list of Dr. Kanold's publications, please visit the publications page of his website.
- DURIP: Optical stimulation to probe function and structure of microcircuits in auditory cortex of the brain
- NIH BRAIN Initiative: new imaging technologies and data analysis techniques
- MURI: Understanding and Controlling the Coupled Electrical, Chemical & Mechanical Excitable Networks of Living Systems