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Depireux, Didier

Didier Depireux
Associate Research Scientist
2205 A.V. Williams Building

Research Interests 

Computational model of hearing and modeling of the central nervous changes associated with the perception of tinnitus.



Didier Depireux joined the Institute for Systems Research in the summer of 2009. He is also an adjunct faculty at the Fischell BioEngineering department. He earned his doctorate in Physics (string
theory) with Dr S.J. Gates and did post-doctoral work in conformal field theory and integrable systems, before turning his attention to computational and wet neuroscience.

Didier Depireux's research focuses on the representation of speech in the auditory midbrain and cortex, and on the changes in the auditory pathway correlated with the induction of tinnitus by noise trauma or blast wave injury. In addition to modeling, progress is achieved by recordings from awake behaving rats, ferrets and mice, using chronic moveable electrode arrays, auditory brainstem response, startle reflex, and immunocytochemistry.

About the Ear Lab
With grant support from the Department of Defense, The Ear Lab measures the changes, at the level of the activity of single neurons over many weeks, that are correlated with the induction of tinnitus (ringing in the ears) following noise trauma. Specifically, the research uses behavioral measures to verify the emergence of tinnitus post-trauma, chronic electrode arrays to measure the activity of large populations of neurons before and after induction of tinnitus, and post-mortem immunocytochemical methods to uncover permanent changes in the brain. The Ear Lab wants to explore new drug delivery methods that might prevent the induction of or provide relief from tinnitus, a common affliction that has received very little scientific attention until recently.

Honors and Awards 

Inaugural Provost’s Excellence Award for Professional Track Faculty (2016)

Selected Publications 

Handbook of Modern Techniques in Auditory Cortex Depireux (ISR), Elhilali (alumna; Johns Hopkins University) Nova Science Pub. 2014


Related News 

Clark School Spinout Developing Pediatric Cancer Drug Delivery System to Prevent Hearing Loss from Chemotherapy
Otomagnetics Awarded $2.3 Million Fast Track NIH/NCI SBIR Contract October 19, 2017

Five ISR faculty part of $8 million NIH grant to combat hearing loss in older people
Multidisciplinary research will examine strategies to improve communication challenges. October 12, 2017

Article about Otomagnetics in Action on Hearing Loss newsletter
Magnetic injection work of Shapiro, Depireux is highlighted. November 14, 2016

Didier Depireux wins inaugural Provost's Excellence Award
The new award is given to professional track faculty for contributions in research, teaching or service. June 2, 2016

Depireux, Masri win $25K UMB UMVentures Award
Award given for commercial potential of dental nanoparticle therapy technology. April 27, 2015

Depireux, Masri win NIH grant for dental drug delivery research
Magnetic nanoparticles could deliver medication inside the tooth; reduce need for root canals. July 14, 2014

Shapiro's Otomagnetics Recipient of BioMaryland Center Award
Otomagnetics receives a Biotechnology Development Award through the BioMaryland Center. March 14, 2014

Depireux, Elhilali co-edit auditory cortex techniques handbook
Book is the first to explain "broadband" techniques used in the study and modeling of the auditory pathway. February 6, 2014

Delivering Drugs to Inner Ear, Eyes, and Brain Made Easier with "Magnetic Syringe"
Clark School startup Otomagnetics wins AdvaMed's Rybski MedTech Award to support further development. October 9, 2013

Shapiro, Depireux team for series of grants to combat hearing loss
Research will advance the delivery of drug therapies to the inner ear. January 17, 2013

ISR appoints three new assistant research scientists
Bandyopadhyay, Depireux, Sterbing-D’Angelo to join faculty in July. June 25, 2009