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5:00 p.m.
First floor Lecture Hall, Kim Building
For More Information:
Regina King
301 405 6615
rking12@umd.edu
http://www.isr.umd.edu/events/dls.htm
Microsystems engineering at the interface of physics, biology and chemistry: Where are we now and where are we heading?
Andreas G. Andreou
Professor, Electrical and Computer Engineering and Computer Science
Whitaker Biomedical Engineering Institute
Center for Language and Speech Processing
Johns Hopkins University
Reception at 4:30 p.m.
Lecture at 5:00 p.m.
Roundtable discussion Tuesday, Dec. 4 at 2:00 p.m., 1146 A.V. Williams Building | details here |
Host
ISR Director Eyad Abed
Abstract
The engineering of life science microsystems, at the interface of physics, chemistry and biology is an active area of research. Cell based biosensors, comprising of hybrid silicon/living cells are promising technologies for environmental monitoring, and hazardous substance early warning systems. In biotechnology, new drug development relies on hybrid microdevices for in-vitro high throughput laboratory studies on cells and tissue. In-vivo microsystems for closed loop sensing and drug delivery, together with bio-informatics are also paving the way to new approaches to disease treatment and health care.
In this talk I will give an overview and highlight recent advances in life-science microsystems. I will then focus the discussion on a hybrid microsystem for autonomous cell culture and incubation fabricated in hybrid silicon/silicone (PDMS) technology. Our approach employs soft-lithography to create disposable microfluidics that incorporate reusable functional silicon structures for sensing, control and actuation. While a first cut design of the system can be done using back of the envelope calculations, the salient behaviour of the individual components is studied using computational methods and finite element analysis. In the talk I will discuss the tradeoffs in the overall design of the electronics and fluidics, as well as the thermal packaging and control aspects of the system.
This presentation is based on the Ph.D. dissertation work of Jennifer Blain Christen.
Biography
Andreas G. Andreou received his Ph.D. in electrical engineering and computer science in 1986 from Johns Hopkins University. Between 1986 and 1989 he held post-doctoral fellow and associate research scientist positions in the Electrical and Computer engineering department while also a member of the professional staff at the Johns Hopkins Applied Physics Laboratory. Andreou became an assistant professor of Electrical and Computer engineering in 1989, associate professor in 1993 and professor in 1996. He is also a professor of Computer Science and of the Whitaker Biomedical Engineering Institute and director of the Institute's Fabrication and Lithography Facility in Clark Hall. He is the co-founder of the Johns Hopkins University Center for Language and Speech Processing. Between 2001 and 2003 he was the founding director of the ABET accredited undergraduate Computer Engineering program. In 1996 and 1997 he was a visiting professor of the computation and neural systems program at the California Institute of Technology. In 1989 and 1991 he was awarded the R.W. Hart Prize for his work on mixed analog/digital integrated circuits for space applications. He is the recipient of the 1995 and 1997 Myril B. Reed Best Paper Award and the 2000 IEEE Circuits and Systems Society, Darlington Best Paper Award. During the summer of 2001 he was a visiting professor in the department of systems engineering and machine intelligence at Tohoku University. In 2006, Prof. Andreou was elected as an IEEE Fellow and a distinguished lecturer of the IEEE EDS society.
Andreou's research interests include sensors, micropower electronics, heterogeneous microsystems, and information processing in biological systems. He is a co-editor of the IEEE Press book: Low-Voltage/Low-Power Integrated Circuits and Systems, 1998 (translated in Japanese) and the Kluwer Academic Publishers book: Adaptive Resonance Theory Microchips, 1998. He is an associate editor of IEEE Transactions on Biomedical Circuits and Systems.
This Event is For: Clark School • Graduate • Faculty • Post-Docs • Alumni • Corporate
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